Sjogren syndrome in the therapeutic practice (clinical case) 

Tat'yana N. Belugina, Candidate of medical sciences, associate professor of the sub-department of internal diseases, Medical Institute, Penza State University (40 Krasnaya street, Penza, Russia), beluginatn@gmail.ru
Yuliya N. Gracheva, Candidate of medical sciences, associate professor of the sub-department of internal diseases, Medical Institute, Penza State University (40 Krasnaya street, Penza, Russia), y.gracheva@mail.ru
Alsu M. Kuryaeva, Candidate of medical sciences, associate professor of the sub-department of internal diseases, Medical Institute, Penza State University (40 Krasnaya street, Penza, Russia) salviya_1@mail.ru
Renata E. Dement'eva, Candidate of medical sciences, associate professor of the sub-department of internal diseases, Medical Institute, Penza State University (40 Krasnaya street, Penza, Russia), rdementyeva@gmail.com
Irina B. Matrosova, Candidate of medical sciences, associate professor of the sub-department of internal diseases, Medical Institute, Penza State University (40 Krasnaya street, Penza, Russia), matrosovaib@mail.ru

Background. Sjogren syndrome (SS) affects approximately 0.5 % of the general population, which makes it one of the most common systemic autoimmune diseases, second only to rheumatoid arthritis. SS is classically considered as a disease of the exocrine glands, manifested mainly by dryness of the mouth and eyes, however, it has a wide range of systemic clinical manifestations that affect almost any organ system, and a small number of cases are complicated by the development of lymphoproliferative diseases, which makes it difficult to verify this disease. The purpose of the study is to analyse clinical manifestations and assessment of difficulties in differential diagnosis of SS in real clinical practice. Material and methods. A case of SS was retrospectively identified with subsequent analysis of a patient with primary SS. Results. Diagnosis of the SS is an interdisciplinary problem that requires timely recognition, analysis of the clinical features of this disease, timely administration of therapy, as well as regular monitoring of this group of patients in order to exclude complications, since the transformation of the SS into lymphoproliferative diseases is several tens of times higher than in the general population.

Sjogren syndrome, autoimmune disease, xerophthalmia (dry eyes), xerostomia (dry mouth) 

Belugina T.N., Gracheva Yu.N., Kuryaeva A.M., Dement'eva R.E., Matrosova I.B. Sjogren syndrome in the therapeutic practice (clinical case). Izvestiya vysshikh uchebnykh zavedeniy. Povolzhskiy region. Meditsinskie nauki = University proceedings. Volga region. Medical sciences. 2022;(3):5–14. (In Russ.). doi:10.21685/2072-3032-2022-2-1